South Main Street runs through the center of Ann Arbor's downtown. It's the east-west dividing line for street numbering.
Currently
- 100 Key Bank
- 200 BD's Mongolian Barbeque
- 214 RUB fitness studio
- 218 The Himalayan Bazaar
- 220 Elmo's Hideaway basement
- 223 Occasionally Gift Shop
- 303 Ten Thousand Villages
- 306 WSG Gallery art gallery
- 306 Busy Hands knitting supplies
- 306 Le Dog
- 315 M-Den clothing
- 318 Conor O'Neill's bar
- 322 The Chop House restaurant
- 328 Prickly Pear restaurant
- 347 Palio restaurant
- 504 Tom Thompson Flowers
- 611 Back Alley Gourmet
- 618 Overture Audio
- 619 Brazamerica
- 625 San Fu
- 637 Ann Arbor School for the Performing Arts
- 704 7-Eleven
- 1026 Blue House Ann Arbor
- 2856 Arbor Dog Daycare
Future
- The Residences at 615 South Main
- 315 S Main St redevelopment
Formerly
- 109 Sugar Bowl Restaurant opened 1911
- 116 Kai Garden
- 120-122 F W Woolworth
- 220 Main Street News
- 326 Orpheum Theatre
- 341 Quality Bakery
- 341 Quality Bar
- 619 Brazamerica
- 704 Austin and Warburton Jewelers
