2010-2011 Record & Schedule for the NFL's Buffalo Bills
| Date/Location |
| Opposing Team |
| Final Score |
| 9/12-Ralph Wilson Stadium (Orchard Park) |
| Miami Dolphins |
| Loss 15-10 |
| 9/19-Lambeau Field, Green Bay, WI |
| Green Bay Packers |
| Loss 34-7 |
| 9/27-Gillette Field, Foxborough, MA |
| New England Patriots |
| Loss 38-30 |
| 10/4-Ralph Wilson Stadium (Orchard Park) |
| NY Jets |
| Loss 38-14 |
| 10/11-Ralph Wilson Stadium (Orchard Park) |
| Jacksonville Jaguars |
| Loss 36-26 |
| 10/17—BYE WEEK |
| 10/24—M&T Bank Stadium (Baltimore) |
| Baltimore Ravens |
| Loss 37-34 |
